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Cleanroom Wipers ISO 3–8 Polyester, Nonwoven, Microfiber & Sterile Cleanroom Wipes Sealed-edge polyester, low NVR wipes, sterile wipes for USP <797>/<800>, and pre-wetted IPA formats. ▼ EXPAND TECHNICAL REFERENCE
ISO 5 Cleanroom Wipes, Sterile Wipes & Low-Lint Polyester Options
Cleanroom wipers are contamination-control tools used to remove particles, non-volatile residues (NVR), ionic contamination, and bioburden without introducing fibers or extractables. Selection should align with ISO classification (ISO 14644-1), surface sensitivity, solvent chemistry, and any documented process requirements.
ISO 3–5 environments typically favor sealed-edge knit polyester wipes for fiber control and consistency.
ISO 6–8 environments often use a broader mix including hydroentangled nonwoven wipes when absorbency and speed matter.
Typical users include semiconductor wafer fabrication, pharmaceutical compounding (USP <797> / <800> programs), biotechnology, medical device manufacturing, aerospace, optics, and advanced electronics.
Fast Selection Guidance
  • Fiber-sensitive surfaces: prioritize sealed-edge polyester.
  • High absorbency needs: consider hydroentangled nonwoven wipes.
  • Repeatable solvent delivery: use pre-wetted IPA wipes to reduce variation.
  • Aseptic handling / sterile transfer: use sterile wipes with validated packaging and documentation.
Sealed Edge Polyester vs Nonwoven vs Microfiber
Sealed-Edge Knit Polyester (Continuous Filament):
Commonly selected for ISO 5 critical wipe-downs. Laser or ultrasonic sealed edges reduce loose fibers and improve consistency. Polyester typically offers broad chemical compatibility and controlled residue profiles.
Hydroentangled Cellulose/Poly Nonwoven:
High absorbency and rapid wet-out. Frequently used in ISO 7–8 support areas for general cleaning tasks where fiber sensitivity is lower.
Microfiber (Split-Fiber Technology):
Increased surface area improves fine particle pickup and can support streak-free cleaning on glass, stainless steel, and optics when paired with approved chemistry.
Pre-Wetted IPA Cleanroom Wipes (70% IPA or validated blends):
Controlled saturation reduces operator variability and supports standardized wipe protocols across shifts.
Sterile Cleanroom Wipes for USP <797> and USP <800>
Sterile wipes are commonly gamma irradiated and validated to a Sterility Assurance Level (SAL) of 10⁻⁶. They are used in aseptic processing, sterile transfer workflows, and compounding environments where sterile handling and documentation are required.
Double-bag packaging supports staged transfer through gowning rooms and airlocks. Always verify certificate documentation and packaging integrity under your internal change-control process.
Cleanroom Wipe Performance Metrics
  • Particle Generation: commonly evaluated using IEST-RP-CC004 methods.
  • Non-Volatile Residue (NVR): important for yield-sensitive semiconductor and optics work.
  • Ionic Extractables: sodium/potassium/chloride control for electronics manufacturing.
  • Sorbency & Wet-Out: impacts solvent distribution and wipe effectiveness.
  • ESD Considerations: select appropriate materials for static-sensitive workflows when required.
Common Audit Findings (and how to prevent them)
  • Wrong edge type for the room: sealed-edge requirements not matched to ISO area or SOP.
  • Uncontrolled wetting: over-wetting spreads residues; under-wetting reduces removal efficiency.
  • Mixing wipe grades: general-purpose wipes introduced into controlled workflows.
  • Missing documentation: sterile/irradiation certs not available at point of use during audits.
Quick Process Alignment
ISO 5 critical surfaces Sealed-edge polyester cleanroom wipes
USP compounding workflows Sterile wipes with validated documentation (often SAL 10⁻⁶)
General ISO 7–8 cleaning Hydroentangled nonwoven wipes
Controlled solvent wipe-downs Pre-wetted IPA wipes
Need Help Selecting ISO 5 or Sterile Wipes?
Contact our cleanroom specialists at Sales@SOSsupply.com or call (214) 340-8574.
SOSCleanroom Disclaimer
This selection guidance is provided for general informational purposes to support purchasing decisions and SOP discussions. Product performance depends on your environment, surfaces, chemistry, application method, and process controls. Customers are responsible for verifying suitability, compatibility, and compliance with internal procedures and regulatory requirements (including validation where applicable). Specifications may change without notice; always refer to current manufacturer documentation and your approved change-control process.