Cidehol 8432 is a non-sterile 70% isopropyl alcohol (IPA) solution supplied in a 32 oz container for routine cleanroom wipe-down and surface cleaning. The 32 oz format is commonly used where teams want more capacity than a 16 oz bottle for shift work, carts, or higher-frequency wipe-downs, while still maintaining point-of-use handling control without repeatedly opening larger bulk containers.

In controlled environments, cleaning outcomes are dominated by method discipline: wetness target (damp film vs. flooding), wipe direction, clean-face rotation, and change-out triggers. Visible defects such as streaks, haze, and residue re-deposit are typically caused by over-wetting, backtracking, and reusing solvent-loaded applicators rather than chemistry concentration alone.

ISO 14644-5 emphasizes that cleaning practices are operational controls that must be standardized and executed consistently to maintain cleanroom conditions. USP <797> and <800> reinforce similar concepts in pharmaceutical environments: surface cleaning and disinfection are technique-dependent and must be performed with defined frequency and documentation to prevent method drift and cross-contamination.

Although Cidehol 8432 is non-sterile and intended for non-sterile cleanroom operations, the same underlying discipline applies. Consistent wetness control and controlled applicator use are the primary levers for repeatable cleaning outcomes.

Best practice for 70% IPA wipe-down begins with controlling how the chemistry is applied. For most cleanroom methods, IPA should be dispensed onto the wiper or swab rather than sprayed directly onto the surface. This supports a consistent damp-film condition and reduces uncontrolled pooling, especially around seams, fasteners, interfaces, and equipment edges. Operators should apply only enough IPA to mobilize contamination without leaving standing liquid.

Wiping should be performed using straight, overlapping strokes in one direction. Backtracking and circular scrubbing increase redeposit risk by spreading dissolved residues. Wipers should be folded consistently and rotated to a clean contact face after each pass. Once a wiper becomes loaded, tacky, loses structure, or begins leaving streaks, it should be discarded and replaced immediately. Used applicators should never be placed back onto benches, carts, or packaging.

For residue-sensitive work, a two-step approach is common: an initial damp pass to mobilize soils followed by a second clean pass to remove dissolved material before it dries into a film. These controls should be defined in SOPs, trained, and periodically audited to reduce shift-to-shift variability.

• Over-wetting surfaces: Causes pooling and residue re-deposit. Prevention includes damp-film control and dispensing IPA to the applicator (ISO 14644-5; USP <797>).
• Backtracking over cleaned areas: Re-deposits dissolved contamination. Prevention includes one-direction wiping and defined stroke patterns (ISO 14644-5).
• Reusing solvent-loaded wipes: Smears contamination instead of removing it. Prevention includes face-rotation rules and early change-out triggers (ISO 14644-5).
• Using non-cleanroom gloves: Introduces particles and residues that negate cleanroom wiper performance. Prevention includes cleanroom-qualified gloves and glove-change discipline (ISO 14644-5 personnel controls).
• Using non-sterile IPA in sterile workflows: Creates regulatory non-conformance. Prevention includes selecting sterile IPA when sterility is required (USP <797> / <800>).
• Leaving open bottles on carts or benches: Increases contamination risk and accelerates evaporation. Prevention includes cap discipline, defined open-time limits where required, and point-of-use control (ISO 14644-5).

SOSCleanroom suggests the following companion products based on cleanroom compatibility, published performance characteristics, and their ability to support consistent 70% IPA technique. The intent is to reduce operator-driven variability and prevent common wipe-down failures such as redeposit, streaking, and localized contamination migration.

• Texwipe TX1009 AlphaWipe® (polyester cleanroom wiper): Continuous-filament polyester construction supports low lint contribution and predictable absorbency, enabling damp-film technique and consistent fold/rotation practices. A 9" x 9" format supports standardized wipe patterns in SOPs.
• Texwipe TX761 Alpha® Long-Handle Swab (polyester knit): Used for localized cleaning in seams, grooves, and interfaces where wipe access is limited. Thermal bond construction (no adhesive) reduces contamination variables in solvent-heavy work and the long handle reduces glove intrusion near critical surfaces.
• Ansell 93-311 Nitrilite® Cleanroom Nitrile Gloves (ISO 5): Gloves are often the dominant contamination vector during wipe-down operations. Cleanroom-qualified gloves reduce operator-introduced particles and residues and help preserve the contamination-control intent of cleanroom wipers and swabs.
• Why a 32 oz format is used: Mid-size containers often reduce refill frequency compared to 16 oz bottles while maintaining point-of-use control. This supports method consistency on carts and during longer cleaning tasks where repeated bottle handling can introduce variability.

This Technical Vault content is provided for general operational guidance and procurement planning only. It does not replace facility SOPs, validation protocols, quality risk assessments, or manufacturer documentation. Always follow applicable ISO standards, USP chapters, SDS instructions, and site-specific procedures. Cidehol 8432 is non-sterile; if sterility is required, select chemistry packaged and documented for sterile workflows and follow facility transfer procedures.