In ISO-classified and aseptic processing areas, 70% isopropyl alcohol remains a daily workhorse for fast turn cleaning, routine disinfection, and final wipe-down before operations resume. The practical risk is not “whether IPA works” — it is whether teams can keep the workflow sterile and consistent (no non-sterile decanting, no touch contamination of sprayers, no improvised contact-time habits, and no missing traceability during audits).

CiDehol® ST is positioned for sterile cleanroom cleaning and disinfection use: a sterile, ready-to-use 70% (v/v) USP isopropyl alcohol solution made with Water-for-Injection (WFI), filtered to 0.2 µm, double-bagged, and gamma irradiated. It is manufactured and packaged with documentation discipline intended to support controlled programs.

• Sterile wipe-down of benches, carts, stainless, pass-through surfaces, and non-porous equipment exteriors in controlled environments.
• Routine disinfection steps in pharmaceutical, biotechnology, and medical device cleanroom operations where sterile alcohol is required.
• Final “reset” wipe after detergent cleaning, before setup, staging, or material transfer into higher-grade areas.
• Programs needing lot-linked documentation covering QC, irradiation, sterility testing, and bacterial endotoxin limits.

• Sterile, ready-to-use formulation: no mixing or in-house filtration steps that can introduce variability.
• WFI-based blend and filtration: described as made with Water-for-Injection (WFI) and filtered to 0.2 µm.
• Gamma irradiation sterility assurance: documented SAL 10⁻⁶; double-bagged to support clean introduction.
• Endotoxin discipline: manufacturer documentation states endotoxin is guaranteed to be <0.25 EU/mL (WFI criterion).
• Lot-specific traceability: each case is shipped with documentation detailing QC, irradiation, sterility, and bacterial endotoxin limits.
• Operational realities covered: Hazmat ground-only shipping and commercial-address requirements align with flammable liquid controls and compliance expectations.

CiDehol® ST is a 70% (v/v) USP isopropyl alcohol solution formulated with high-purity water (WFI per manufacturer documentation). The solution is processed through 0.2 µm filtration, then bottled and double-bagged in a cleanroom environment and terminally sterilized by gamma irradiation.

• Alcohol content: 70% isopropyl alcohol, USP (v/v).
• Water content: WFI per manufacturer technical data sheet; SOSCleanroom ingredient line lists purified water, USP.
• Sterility processing: gamma irradiated to SAL 10⁻⁶; double-bagged for cleaner transfer.
• Safety profile (SDS): flammable liquid and vapor; causes skin and eye irritation; handle with appropriate PPE and ventilation.

70% IPA is widely used because it evaporates quickly and, when properly applied, supports effective routine disinfection on non-porous surfaces. It is not a sporicide, so high-performing programs typically use sterile IPA as a frequent “daily driver” while rotating in an appropriate sporicidal disinfectant per facility risk and regulatory expectations.

• Coverage beats speed: incomplete wetting and “spray-and-wave” habits leave untreated islands that become recontamination sources.
• Contact time is still real: even fast-evaporating alcohol needs a deliberate, wet contact interval on the surface to be meaningful.
• Bioburden and soil load matter: if a surface has visible residue, clean first; disinfecting over soil is unreliable and increases residue smearing.
• Residue control: alcohol is typically low residue, but your acceptance criteria should be defined (visual inspection, NVR limits, or other facility-defined checks).

• Pack format: four 1-gallon bottles per case (3.8 L each) per SOSCleanroom listing and manufacturer documentation.
• Sterility handling: processed via gamma irradiation to SAL 10⁻⁶; bottled and double-bagged in a cleanroom; each lot is tested for sterility (USP 14-day sterility test) and bacterial endotoxin (LAL) prior to release per manufacturer documentation.
• Traceability: each case is shipped with lot-specific documentation detailing QC, irradiation, sterility, and bacterial endotoxin limits.
• Shipping controls (Hazmat): SOSCleanroom requires ground shipping only, commercial address only, and adds a $35.00 Hazmat shipping charge per case.
• Transport classification (SDS): UN1219, Isopropanol, Class 3, Packing Group II.
• Country of origin: not stated in source basis.

The best sterile IPA technique is the one your quality system can repeat: controlled opening, controlled application, controlled wipe pattern, and controlled discard. The points below are practical habits that reduce common contamination and documentation failures while staying aligned with typical cleanroom discipline and SDS safety expectations. Always follow your validated internal procedure and the manufacturer’s documentation.

1. Introduce the case cleanly: verify outer packaging integrity at receiving; retain lot documentation; stage the inner bag for cleanroom entry using your facility’s approved transfer method.
2. Open without touch contamination: treat sprayers, caps, and bottle mouths as critical surfaces. If you add or change a dispensing closure, do it under controlled conditions consistent with your SOP and risk profile.
3. Use a disciplined wipe pattern: apply enough solution to keep the surface visibly wet, then wipe in one direction with overlapping passes (do not “scrub in circles” and redeposit soil). Change wipes frequently — if a wipe looks loaded, it is already past its useful life.
4. Separate cleaning from disinfection: if residue or grime is present, clean first with your approved cleaner, then disinfect with sterile IPA. This avoids smearing and improves repeatability.
5. Control evaporation and dwell: on large surfaces, work in sections so the surface remains wet long enough to be meaningful. If the surface dries immediately, you are not achieving practical contact.
6. Safety fundamentals: maintain ventilation; keep away from ignition sources; use eye protection and gloves as required by your hazard assessment and SDS guidance.

• Touch contamination at dispensing points: sprayer heads and caps contact gloves, carts, or benchtops; sterile workflow is compromised without anyone noticing.
• Spray-only habits: alcohol is misted without a controlled wipe, leaving uneven coverage and redeposition risk.
• Cleaning skipped: disinfectant is applied over soil; residues are smeared, and disinfection becomes inconsistent.
• Improvised transfers/decanting: solution is moved into unqualified secondary containers; lot traceability and sterility controls break.
• Ignoring flammability controls: use near ignition sources or poor ventilation increases safety risk; shipping/handling controls exist for a reason.
• Documentation gaps: lot paperwork is not retained, or opened containers are not controlled per internal rules, creating audit exposure.

Comparable sterile alcohol solutions are differentiated less by “70% IPA” and more by packaging controls, sterility assurance approach, documentation support, and delivery-system integrity during use. Two common alternatives in similar programs include:

• Ecolab Klercide™ 70/30 IPA (WFI blend): sterile alcohol positioned for cleanroom disinfection programs, offered with delivery-system features depending on configuration.
• Contec® Sterile 70% Isopropanol: sterile 70% isopropanol with 0.2 µm filtration and gamma irradiation positioning, with lot coding and cleanroom packaging controls.

CiDehol® ST 8301 aligns best with facilities that require a sterile alcohol solution supported by controlled processing (0.2 µm filtration, cleanroom packaging, gamma irradiation), and that must demonstrate traceability and repeatability under a quality system. Typical fits include pharmaceutical sterile compounding support areas, biotech cleanrooms, and medical device clean manufacturing where sterile handling discipline is expected.

Fit is strongest when the facility has defined rules for (1) clean introduction (bag removal steps), (2) dispensing control, (3) wipe technique, and (4) rotation logic (recognizing alcohol is not sporicidal). If your environment requires a sporicide step, sterile IPA should be treated as one component of a documented, risk-based program.

• SOSCleanroom product page (CiDehol ST 8301): https://www.soscleanroom.com/product/solutions/cidehol-st-8301-sterile-70-isopropyl-alcohol-solution-1-gallon-bottle-4-case/
• Decon Labs product page (CiDehol ST): https://deconlabs.com/products/disinfectant-cidehol-st/
• Decon Labs Technical Data Sheet (CiDehol ST 70 WFI): https://deconlabs.com/tds/CiDehol_ST_70_WFI_Tech_sheet.pdf
• Decon Labs Safety Data Sheet (CiDehol ST): https://deconlabs.com/sds/CiDehol%20ST%20SDS.pdf
• SOS-hosted Safety Data Sheet copy: https://www.soscleanroom.com/content/Decon_pdf/CiDehol%20ST_SDS.pdf
• SOS-hosted Technical Data Sheet copy: https://www.soscleanroom.com/content/Decon_pdf/Cidehol%20ST%2070%20WFI%20Tech%20sheet.2011%20doc.pdf
• ISO: https://www.iso.org/standard/53394.html
• FDA: https://www.fda.gov/
• ASTM: https://www.astm.org/
• IEST: https://www.iest.org/