Texwipe TX117 is a non-sterile 70% isopropyl alcohol (IPA) / 30% purified water solution supplied in one-gallon bottles (four per case) for routine cleanroom wipe-down and surface cleaning. This chemistry is commonly selected because the 70/30 composition supports effective cleaning of many light residues while helping control drying behavior, reducing static compared to 100% IPA in some applications, and supporting repeatable wipe-down results when used with disciplined technique.

In real cleanroom operations, outcomes are driven less by the label concentration and more by application method. Over-wetting, inconsistent wipe patterns, backtracking, and reuse of solvent-loaded applicators are the most common drivers of streaks, haze, and residue re-deposit. TX117 performs best when treated as a controlled input to a defined, trained, and documented cleaning method.

ISO 14644-5 emphasizes that cleaning is an operational control that must be standardized and appropriate to the surfaces, equipment geometry, and process risks present in the cleanroom. USP <797> and <800> reinforce similar principles in pharmaceutical environments: surface cleaning and disinfection must be executed with disciplined technique, defined frequency, and documentation to prevent cross-contamination and method drift.

While TX117 is non-sterile and intended for non-sterile cleanroom operations, the same concept applies: consistent results require the chemistry to be paired with compatible applicators and cleanroom-qualified gloves, and to be used in a controlled, repeatable manner.

Best practice for 70% IPA wipe-down begins with controlling how the chemistry is applied. For most operations, IPA should be dispensed onto the wiper or swab rather than applied directly to the surface, which helps prevent uncontrolled pooling and solvent migration into seams and interfaces. Operators should target a damp-film condition that mobilizes contamination without dripping or flooding.

Wiping should be performed using straight, overlapping strokes in one direction, avoiding circular scrubbing or backtracking that can redistribute dissolved residues. Wipers should be folded in a consistent pattern and rotated to a clean contact face after each pass. Applicators should be replaced promptly once they become visibly loaded, tacky, or begin leaving streaks, and used wipes should never be placed back onto benches or carts.

Where residue sensitivity is high, a two-step approach is often used: a first damp wipe to mobilize soils, followed by a second wipe or swab to remove dissolved material before it dries into a film. These method controls should be documented in the site SOP and reinforced through operator training to minimize shift-to-shift variability.

• Over-wetting surfaces: Causes pooling and residue re-deposit. Prevention includes damp-film control and dispensing to the applicator (ISO 14644-5; USP <797>).
• Backtracking over a cleaned area: Re-deposits dissolved contamination. Prevention includes one-direction wiping and defined stroke patterns (ISO 14644-5).
• Reusing a loaded wiper: Smears residues instead of removing them. Prevention includes face-rotation rules and early change-out triggers (ISO 14644-5).
• Using non-cleanroom gloves: Introduces particles and ionic residues during wipe-down. Prevention includes cleanroom-qualified gloves and glove-change discipline (ISO 14644-5 personnel controls).
• Using non-sterile IPA in sterile workflows: Creates regulatory non-conformance. Prevention includes selecting sterile IPA when sterility is required (USP <797> / <800>).

SOSCleanroom suggests the following companion products based on published specifications, cleanroom compatibility, and their ability to support repeatable 70% IPA wipe-down technique. These pairings reduce operator-driven variability and help prevent common failure modes such as re-deposit, streaking, and localized contamination migration.

• Texwipe TX1009 AlphaWipe®: A continuous-filament polyester wiper designed for cleanroom use, offering low lint contribution and predictable absorbency that supports damp-film technique and consistent fold/rotation practices.
• Texwipe TX761 Alpha® Long-Handle Swab: A knit polyester, thermally bonded swab that enables localized cleaning of seams, grooves, and interfaces where wipe access is limited, reducing the risk of glove intrusion and solvent pooling in confined geometries.
• Ansell 93-311 Nitrilite® Cleanroom Nitrile Gloves: Cleanroom-qualified gloves selected to reduce operator-introduced particles and extractables during wipe-down operations, preserving the contamination-control intent of cleanroom-grade wipers and swabs.
• Why a gallon format matters: One-gallon packaging is often used to support controlled replenishment into approved secondary dispensers (spray bottles, pumps, or pour spouts) to standardize wetness targets and reduce uncontrolled spraying or over-application.

This Technical Vault content is provided for general operational guidance and procurement planning only. It does not replace facility SOPs, validation protocols, quality risk assessments, or manufacturer documentation. Always follow applicable ISO standards, USP chapters, SDS instructions, and site-specific procedures. TX117 is non-sterile; if sterility is required, select chemistry packaged and documented for sterile workflows and follow facility transfer procedures.