Category Overview
Cleanroom Solutions
IPA, Ethanol, DI Water, Disinfectants & Specialty Cleaning Chemistries
Validated Chemistries Residue Control Ready-to-Use & Concentrates
Cleanroom solutions are controlled chemistries used for cleaning, disinfecting, and residue removal in regulated and contamination-sensitive environments. Proper selection depends on the chemical composition, concentration, application method, and residue profile required by your SOP and regulatory framework.
Best suited for: ISO 4–8 cleanrooms in pharmaceutical and biotech manufacturing, sterile compounding, medical device assembly, semiconductor and microelectronics, aerospace, optics, and laboratory environments.
Common cleanroom solution applications:
- Routine surface cleaning and wipe-downs
- Disinfection and microbial control
- Residue and particulate removal prior to assembly
- Final cleaning steps before sterile or critical processes
- Controlled solvent delivery for repeatable workflows
General cleaning & wipe-downs
→ 70% IPA or ethanol solutions
Residue-sensitive processes
→ DI water or low-residue solvents
Aseptic / microbial control
→ Validated disinfectants (sterile if required)
Selection Guide
How to choose the right cleanroom solution
Selecting a cleanroom solution requires balancing cleaning effectiveness, material compatibility, residue control, and regulatory expectations. The guidance below helps align chemistry choice with process requirements. For background concepts, see our cleanroom basics and selection guidance.
Why solution selection affects cleanroom performance
Cleaning solutions directly influence residue levels, surface compatibility, and microbial control. Incorrect chemistry can leave non-volatile residue, damage sensitive materials, or create compliance gaps in regulated environments.
- Chemical compatibility: prevents surface damage and degradation
- Residue profile: affects downstream yield and inspection
- Concentration: impacts cleaning effectiveness and safety
- Sterility: required for aseptic and validated processes
Common mistakes to avoid
- Using non-cleanroom-grade solvents in controlled environments
- Ignoring residue and extractables for sensitive assemblies
- Mixing incompatible chemistries within the same SOP
- Over- or under-diluting concentrates outside validated ranges
Quick match: align the solution to the task
| Task | Recommended direction | Why it fits |
|---|---|---|
| Routine wipe-downs | 70% IPA or ethanol | Effective cleaning with controlled evaporation |
| Residue-sensitive cleaning | DI water or low-residue solvent | Minimizes non-volatile residue |
| Disinfection & microbial control | Validated disinfectant | Supports compliance and microbial reduction |
| Repeatable solvent delivery | Pre-packaged or pre-wetted formats | Reduces operator variability |
Best-practice solution handling (SOP fundamentals)
- Follow validated concentrations: do not improvise dilutions
- Use compatible containers: avoid leaching or degradation
- Control application volume: prevent pooling and residue
- Label and track lot numbers: support audits and investigations
- Observe shelf life: expired solutions can lose effectiveness
For the fastest recommendation, be ready to share: surface material, chemistry required, residue sensitivity, and sterility needs.
Need help selecting?
Talk to a cleanroom specialist
Email Sales@SOSsupply.com or call (214) 340-8574 for assistance selecting the right cleanroom solution.