Ansell CE5-755 Microflex Class 100 Nitrile Gloves Cleanroom (ISO 5)

Ansell CE5-755 Microflex® cleanroom nitrile gloves are designed for Class 100 / ISO 5 and cleaner environments, where gloved hands are one of the most frequent contact points with tools, consumables, and product-critical surfaces. In ISO 5 work, glove selection impacts more than “comfort”—it can influence particles, residues, grip behavior, and technique repeatability across operators and shifts.

When cleaning, assembly, or inspection processes are defect-sensitive, the glove becomes part of the process method. A glove that provides consistent fit and controlled surface behavior helps operators maintain predictable contact pressure, reduces overhandling, and lowers the chance of residue transfer. These are the quiet controls that prevent “mystery defects” and reduce rework loops.

ISO 14644 operations guidance identifies personnel as a primary contamination source in cleanrooms. Gloves provide the boundary layer between operators and controlled surfaces. If glove cleanliness, donning discipline, and change frequency are not controlled, the glove can become a high-frequency contamination conveyor—touching carts, sleeves, packaging edges, tools, and then critical surfaces.

USP-driven environments apply the same logic: controlled hand contact and defined glove behavior support repeatability. Even when sterility is not required, residue transfer and glove loading can compromise visual inspection, cleaning validation, and analytical sampling outcomes.

Best practice begins with proper donning per your cleanroom gowning SOP. Hands should be clean and dry prior to donning, and gloves should be pulled on without snapping, which can generate particles. Once donned, gloves should only contact approved cleanroom surfaces, tools, and materials. Avoid “touch drift” where operators touch carts, packaging edges, or gown surfaces and then return to product-contact work without changing gloves.

Define glove change triggers and enforce them. Common triggers include: after touching non-controlled surfaces, after leaving the controlled zone, after solvent-heavy cleaning tasks, after defined time intervals (risk-based), and immediately after any glove compromise. Progressive glove loading (residue, particles, or tackiness) is a common root cause of inconsistent outcomes.

For precision cleaning and inspection-sensitive work, treat gloves as a consumable process control. Extending glove use to “save cost” often increases rework and introduces unpredictable variability.

SOSCleanroom commonly pairs ISO 5 glove programs with controlled swabbing, wiping, and solvent practices to reduce variables. The glove controls the touch interface; the tools control geometry and pickup; the solution controls solvency and drying behavior.

• Suggested swab (precision contact control): Texwipe TX761 Alpha® Polyester Cleanroom Swab (Long Handle) — supports controlled contact in grooves and features while limiting glove intrusion near critical surfaces.
• Suggested wiper (controlled follow-up pickup): Texwipe TX1010 Vectra® Alpha® 10 Polyester Cleanroom Wiper — sealed-edge control for wipe-down steps where fiber control and consistent pickup are required.
• Suggested solution (wetness control / surface prep): Texwipe TX167 Non-Sterile 70% IPA (16 oz) — commonly used for controlled damp-film technique in non-sterile workflows; if your process requires sterile chemistry or disinfectant controls, follow SOP and select approved sterile-presented chemistries.

This Technical Vault content is provided as supplemental operational guidance only and does not replace manufacturer instructions, facility SOPs, validation protocols, quality risk assessments, or regulatory requirements. Always follow applicable ISO standards, USP chapters, and site-specific procedures. Refer to current manufacturer documentation for sterility status, performance data, and chemical compatibility. Control substitutions and document receiving/lot traceability where required.